OPINION Rethinking how DNA methylation patterns are maintained

被引：535

作者：

Jones, Peter A. ^{[1
]}

Liang, Gangning ^{[1
]}

机构：

[1] Univ So Calif, Dept Urol Biochem & Mol Biol, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DE-NOVO METHYLATION; EMBRYONIC STEM-CELLS; HUMAN CANCER-CELLS; MAINTENANCE METHYLATION; METHYLTRANSFERASE GENE; HISTONE METHYLTRANSFERASE; IMMUNODEFICIENCY SYNDROME; EPIGENETIC INHERITANCE; MAMMALIAN DEVELOPMENT; SRA DOMAIN;

D O I：

10.1038/nrg2651

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA.

引用

收藏

页码：805 / 811

页数：7

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