LpA-I levels do not reflect pre beta 1-HDL levels in human plasma

被引：23

作者：

Miida, T ^{[1
]}

Inano, K ^{[1
]}

Yamaguchi, T ^{[1
]}

Tsuda, T ^{[1
]}

Okada, M ^{[1
]}

机构：

[1] KIDO HOSP,DEPT CARDIOL,NIIGATA 950,JAPAN

来源：

ATHEROSCLEROSIS | 1997年 / 133卷 / 02期

关键词：

coronary artery disease; pre beta-HDL; LpA-I; reverse cholesterol transport; CETP deficiency; apolipoprotein A-I; LCAT;

D O I：

10.1016/S0021-9150(97)00133-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-density lipoprotein (HDL) containing apo A-I but no apo A-II (LpA-I) can promote cholesterol efflux from cells, while HDL containing apo A-I and apo A-II can not. Pre beta 1-HDL, a minor fraction of LpA-I, is the initial acceptor of cellular cholesterol. To determine whether the pre beta 1-HDL:LpA-I ratio is constant in human plasma, we measured LpA-I levels by differential electroimmunoassay, and HDL subfraction levels by nondenaturing 2-dimensional gel electrophoresis in 26 subjects. We found that the pre beta 1-HDL:LpA-I ratio was higher in hypercholesterolemia (0.21 +/- 0.09; n = 11, P < 0.05), coronary artery disease (0.26 +/- 0.13; n = 5, P = 0.08) and hypertriglyceridemia (0.39 +/- 0.22; n = 3, P = 0.16) than in normolipidemia (0.11 +/- 0.03, n = 5). LpA-I levels were significantly correlated with HDL2b (r = 0.771, P = 0.000001), HDL2a (r = 0.438, P < 0.01), and pre beta 2-HDL levels (r = 0.496, P < 0.005) but not with pre beta 1-HDL or HDL3 levels. In conclusion, the pre beta 1-HDL:LpA-I ratio is not constant in human plasma. These findings strongly suggest that size distribution of LpA-I may change in various disorders. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：221 / 226

页数：6