Pilot trial to compare tolerance of chlorhexidine gluconate to povidone-iodine antisepsis for central venous catheter placement in neonates

被引：48

作者：

Garland, J. S. ^{[1
]}

Alex, C. P. ^{[1
]}

Uhing, M. R. ^{[2
]}

Peterside, I. E. ^{[3
]}

Rentz, A. ^{[4
]}

Harris, M. C. ^{[5
]}

机构：

[1] St Joseph Hosp, Dept Pediat, Wheaton Franciscan Hlth Care, Milwaukee, WI 53210 USA

[2] Med Coll Wisconsin, Dept Pediat, Div Neonatol, Milwaukee, WI 53226 USA

[3] Hosp Univ Penn, Philadelphia, PA 19104 USA

[4] Harvard Univ, Sch Med, Joint Program Neonatol, Boston, MA USA

[5] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Neonatol & Newborn Serv, Philadelphia, PA 19104 USA

来源：

JOURNAL OF PERINATOLOGY | 2009年 / 29卷 / 12期

关键词：

bloodstream infection; healthcare-related infection; nosocomial infection; contact dermatitis; BIRTH-WEIGHT INFANTS; CARE UNIT PATIENTS; RANDOMIZED TRIAL; INTENSIVE-CARE; SEMIQUANTITATIVE CULTURE; TOPICAL IODINE; INFECTION; PREVENTION; HYPOTHYROIDISM; DIAGNOSIS;

D O I：

10.1038/jp.2009.161

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The purpose of this pilot trial was to determine whether rates of contact dermatitis following cutaneous antisepsis for central catheter placement were similar among neonates treated with chlorhexidine gluconate and povidone-iodine. Chlorhexidine gluconate absorption was also evaluated. Study Design: Infants weighing >= 1500 g and >= 7 days of age were randomized to a 10% povidone-iodine or 2% chlorhexidine gluconate site scrub before catheter placement. Primary outcomes evaluated included dermatitis, catheter colonization and chlorhexidine gluconate absorption. Result: A total of 48 neonates were enrolled. Colonization rates were similar among treatment groups (P<0.6). Dermatitis did not occur at chlorhexidine gluconate (central catheters, n = 24; peripheral catheters, n = 29) sites. Seven neonates had measurable chlorhexidine gluconate concentrations (range 13 to 100 ng ml(-1)) during catheterization. Conclusion: In this small trial chlorhexidine gluconate antisepsis was tolerated by study neonates. Chlorhexidine gluconate was cutaneously absorbed. Larger trials are needed to determine efficacy and tolerance of chlorhexidine gluconate in neonates. Journal of Perinatology (2009) 29, 808-813; doi: 10.1038/jp.2009.161; published online 8 October 2009

引用

页码：808 / 813

页数：6

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