Flow injection spectroscopic analysis of model drugs using on-line UV-diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry

被引：13

作者：

Louden, D

Handley, A

Taylor, S

Lenz, E

Miller, S

Wilson, ID

Sage, A

机构：

[1] AstraZeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

[2] LGC, Runcorn WA7 4QD, Cheshire, England

[3] Micromass UK Ltd, Manchester M23 9LZ, Lancs, England

来源：

ANALYST | 2000年 / 125卷 / 05期

关键词：

D O I：

10.1039/b000696n

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A prototype flow injection analysis (FIA) system for the characterisation of compounds via a combination of diode array UV, H-1 NMR, FT-IR spectroscopy and time-of-flight (TOF) mass spectrometry has been investigated using a number of pharmaceuticals and related compounds as model compounds. This combination of spectrometers allowed the on-flow collection of UV, H-1 NMR, IR and mass spectra together with atomic composition data, enabling almost complete structural characterisation to be performed. Practical detection limits with the current system were in the region of 50 mu g, however, the use of state of the art spectrometers would result in a significant reduction in the amount of material required.

引用

页码：927 / 931

页数：5

共 19 条

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