High incidence of JC viruria in JC-seropositive older individuals

被引：55

作者：

Chang, H

Wang, ML

Tsai, RT

Lin, HS

Huan, JS

Wang, WC

Chang, DC

机构：

[1] Natl Chung Cheng Univ, Inst Mol Biol, Chiayi 621, Taiwan

[2] Chung Shan Med Univ Hosp, Dept Pathol, Taichung, Taiwan

[3] Chung Shan Med Univ, Dept Microbiol & Immunol, Taichung, Taiwan

[4] Chung Shan Med Univ, Dept Internal Med, Taichung, Taiwan

[5] Chia Yi Christian Hosp, Dept Internal Med, Chiayi, Taiwan

[6] Chia Yi Christian Hosp, Dept Pathol, Chiayi, Taiwan

来源：

JOURNAL OF NEUROVIROLOGY | 2002年 / 8卷 / 05期

关键词：

immunosuppression; JC virus; seroprevalence; viruria;

D O I：

10.1080/13550280260422758

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prevalence of the human JC virus (JCV) in the general population at various ages was investigated. Polymerase chain reaction was employed to detect viral DNA in the urine. The results showed that the incidence of JC viruria was low in the young population, but it was high in the elderly. Hemagglutination inhibition assay was performed for JCV seroprevalence study. The results showed that the seropositive rate of JCV was lower in children than that in adults. The ratio of viruria to seropositive for JCV increased with age and reached 79.7% for those older than 70 years. The results indicated that aging immunity may correlate with JCV reactivation.

引用

页码：447 / 451

页数：5

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[12] A regulatory region rearranged BK virus is associated with tubulointerstitial nephritis in a rejected renal allograft [J].