Principles and methods of evolutionary biotechnology

被引：14

作者：

Koltermann, A

Kettling, U

机构：

[1] Max-Planck-Inst. Biophysik. Chem., Abteilung Biochemische Kinetik

来源：

BIOPHYSICAL CHEMISTRY | 1997年 / 66卷 / 2-3期

关键词：

evolutionary biotechnology; applied molecular evolution; drug design; combinatorial libraries; combinatorial biosynthesis; high throughput selection;

D O I：

10.1016/S0301-4622(97)00063-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolutionary biotechnology applies the principles of molecular evolution to biotechnology, leading to novel techniques for the creation of biomolecules with a great variety of functions for technical and medical purposes. Several basic principles for the application of evolutionary strategies can be derived from a comprehensive theory of molecular evolution. Prerequisites for evolutionary biotechnology are summarized with respect to the different classes of biomolecules and a few, selected applications are described in detail. Concepts for the technical implementation of evolutionary strategies are presented which allow automatized, high throughput processes. (C) 1997 Published by Elsevier Science B.V.

引用

页码：159 / 177

页数：19

共 192 条

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