Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains

被引：66

作者：

Beer, Ronny

Engelhardt, Klaus W.

Pfausler, Bettina

Broessner, Gregor

Helbok, Raimund

Lackner, Peter

Brenneis, Christian

Kaehler, Stefan T.

Georgopoulos, Apostolos

Schmutzhard, Erich

机构：

[1] Innsbruck Med Univ, Dept Clin Neurol, Neurol Intens Care Unit, A-6020 Innsbruck, Austria

[2] Leopold Franzens Univ Innsbruck, Inst Pharm, Dept Pharmacol & Toxicol, Innsbruck, Austria

[3] Med Univ Vienna, Div Infect Dis, Dept Med 1, Vienna, Austria

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 01期

关键词：

D O I：

10.1128/AAC.00515-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (standard deviation) was 63 +/- 18.9 mg (.) h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.

引用

页码：379 / 382

页数：4

共 24 条

[1] Cerebrospinal fluid penetration and pharmacokinetics of vancomycin administered by continuous infusion to mechanically ventilated patients in an intensive care unit [J].