What MAN1 does to the smads -: TGFβ/BMP signaling and the nuclear envelope

被引:40
作者
Bengtsson, Luiza [1 ]
机构
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
关键词
BMP; laminopathy; MAN1; nuclear envelope; phosphatase; signal transduction; Smad; TGF beta; TO-AUTOINTEGRATION FACTOR; MEMBRANE PROTEIN MAN1; RNA-RECOGNITION MOTIF; LEM-DOMAIN PROTEIN; A-TYPE LAMINS; DEPENDENT LOCALIZATION; MUSCULAR-DYSTROPHY; INTEGRAL PROTEIN; GENE-EXPRESSION; EMERIN;
D O I
10.1111/j.1742-4658.2007.05696.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGF beta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGF beta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGF beta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGF beta/BMP signaling is proposed.
引用
收藏
页码:1374 / 1382
页数:9
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