Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes

被引：26

作者：

Blay, Gonzalo ^{[1
]}

Cardona, Luz ^{[1
]}

Fernandez, Isabel ^{[1
]}

Marco-Aleixandre, Alicia ^{[1
]}

Carmen Munoz, M. ^{[2
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, E-46100 Valencia, Spain

[2] Univ Politecn Valencia, Dept Fis Aplicada, E-46071 Valencia, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 20期

关键词：

AMINO-ALCOHOL; ASYMMETRIC ALKYNYLATION; TITANIUM COMPLEX; PHENYLACETYLENE ADDITION; ALKYNYLZINC ADDITION; PROPARGYLIC ALCOHOLS; OXAZOLIDINE LIGANDS; CARBONYL GROUPS; DIMETHYLZINC; KETONES;

D O I：

10.1039/b911592g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mandelamide ligand, derived from (S)-mandelic acid and (S)-phenylethanamine, catalyzes the addition of aryl-, alkyl-and silyl-alkynylzinc reagents to aromatic and heteroaromatic aldehydes with good yields and good to high enantioselectivities.

引用

页码：4301 / 4308

页数：8

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