Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease

被引：20

作者：

Balietti, Marta ^{[1
]}

Giuli, Cinzia ^{[2
]}

Fattoretti, Patrizia ^{[1
]}

Fabbietti, Paolo ^{[3
]}

Papa, Roberta ^{[4
]}

Postacchini, Demetrio ^{[2
]}

Conti, Fiorenzo ^{[1
,5
]}

机构：

[1] INRCA Ancona, Ctr Neurobiol Aging, Via Birarelli 8, I-60121 Ancona, Italy

[2] INRCA, Geriatr Operat Unit, Fermo, Italy

[3] INRCA Ancona, Lab Biostat, Ancona, Italy

[4] INRCA Ancona, Ctr Socioecon Gerontol Res, Ancona, Italy

[5] Univ Politecn Marche, Sect Neurosci & Cell Biol, Dept Expt & Clin Med, Ancona, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 57卷 / 01期

关键词：

Alzheimer disease; comprehensive intervention; brain; derived neurotrophic factor; plasma; time; NEUROTROPHIC FACTOR LEVELS; MILD COGNITIVE IMPAIRMENT; VAL66MET POLYMORPHISM; SERUM CONCENTRATIONS; HUMAN PLATELETS; BLOOD-BRAIN; DEMENTIA; RISK; STIMULATION; AGE;

D O I：

10.3233/JAD-161168

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasma brain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.

引用

页码：37 / 43

页数：7

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