Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze

被引：38

作者：

Miyasaka, K

Kobayashi, S

Ohta, M

Kanai, S

Yoshida, Y

Nagata, A

Matsui, T

Noda, T

Takiguchi, S

Takata, Y

Kawanami, T

Funakoshi, A

机构：

[1] Tokyo Metropolitan Inst Gerontol, Dept Clin Physiol, Tokyo 1730015, Japan

[2] Tokyo Metropolitan Inst Gerontol, Dept Cell Recognit, Tokyo 1730015, Japan

[3] Kobe Univ, Sch Med, Third Div, Dept Med, Kobe, Hyogo 650, Japan

[4] Tohoku Univ, Sch Med, Dept Mol Genet, Sendai, Miyagi 9808575, Japan

[5] Kyushu Natl Canc Ctr, Res Inst, Fukuoka 8111395, Japan

[6] Kyushu Natl Canc Ctr, Dept Gastroenterol, Fukuoka 8111395, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 335卷 / 02期

关键词：

behavior; cholecystokinin; cholecystokinin-A receptor; cholecystokinin-B receptor; anxiety;

D O I：

10.1016/S0304-3940(02)01176-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholecystokinin (CCK)-A receptor (AR) and B receptor (BR) share highly amino acid sequence homology and overlap in their tissue distribution. We examined the anxiety-related behavior of CCK-AR, CCK-BR, and CCK-ARBR gene knockout (-/-) mice in the elevated plus-maze. CCK-AR(-/-) mice showed a significantly higher frequency of open-arm entries than wild-type and CCK-BR(-/-) mice, whereas the percentage open-arm entry values in CCK-AR(-/-) mice did not differ from those in wild-type mice. Thus, this increased frequency in open-arm entries for CCK-AR(-/-) mice was interpreted to be due to an increase in locomotor activity, rather than to a reduction in anxiety. By contrast, CCK-BR(-/-) mice showed significantly lower percentage open-arm entry values and spent significantly less time in the open- arms than wild-type and CCK-AR(-/-) mice. We therefore conclude that a lack of CCK-BR increases the anxiety-related behavior of the mouse in the elevated plus- maze. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：115 / 118

页数：4

共 19 条

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