Why Aire? Compensating for late bloomers

被引：14

作者：

Cohn, Melvin ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Conceptual Immunol Grp, La Jolla, CA 92037 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 11期

关键词：

Aire regulation; Autoimmunity; Negative selection; T-cell tolerance; Transcription factor; SELF-NONSELF DISCRIMINATION; THYMIC EPITHELIAL-CELLS; H TH GENESIS; COMPUTERIZED MODEL; TOLERANCE; EXPRESSION; AUTOANTIBODIES; AUTOIMMUNITY; ANTIGEN; LEVEL;

D O I：

10.1002/eji.200939628

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The question under analysis in this commentary is, what was the evolutionary selection pressure that necessitated the ectopic expression of a subset of peripheral self-antigens in the thymus and by peripheral APC? The suggestion is that antigen expression is delayed until after the immune system is responsive.

引用

页码：2969 / 2972

页数：4

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