Why Aire? Compensating for late bloomers

被引:14
作者
Cohn, Melvin [1 ]
机构
[1] Salk Inst Biol Studies, Conceptual Immunol Grp, La Jolla, CA 92037 USA
关键词
Aire regulation; Autoimmunity; Negative selection; T-cell tolerance; Transcription factor; SELF-NONSELF DISCRIMINATION; THYMIC EPITHELIAL-CELLS; H TH GENESIS; COMPUTERIZED MODEL; TOLERANCE; EXPRESSION; AUTOANTIBODIES; AUTOIMMUNITY; ANTIGEN; LEVEL;
D O I
10.1002/eji.200939628
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
The question under analysis in this commentary is, what was the evolutionary selection pressure that necessitated the ectopic expression of a subset of peripheral self-antigens in the thymus and by peripheral APC? The suggestion is that antigen expression is delayed until after the immune system is responsive.
引用
收藏
页码:2969 / 2972
页数:4
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