Group B Streptococcus:: global incidence and vaccine development

被引：255

作者：

Johri, Atul Kumar ^{[1
]}

Paoletti, Lawrence C.

Glaser, Philippe

Dua, Meenakshi

Sharma, Puja Kumari

Grandi, Guido

Rappuoli, Rino

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

[2] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab,Dept Med, Boston, MA 02115 USA

[4] Inst Pasteur, URA CNRS 2171, Unite Genom Microorganismes Pathogenes, F-75724 Paris, France

[5] Novartis Vaccines, I-53100 Siena, Italy

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrmicro1552

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An ongoing public health challenge is to develop vaccines that are effective against infectious diseases that have global relevance. Vaccines against serotypes of group B Streptococcus ( GBS) that are prevalent in the United States and Europe are not optimally efficacious against serotypes common to other parts of the world. New technologies and innovative approaches are being used to identify GBS antigens that overcome serotypespecificity and that could form the basis of a globally effective vaccine against this opportunistic pathogen. This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens.

引用

页码：932 / 942

页数：11

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