Mechanisms of sensory transduction in the skin

被引:588
作者
Lumpkin, Ellen A.
Caterina, Michael J.
机构
[1] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Human Genet, Houston, TX 77030 USA
[4] Johns Hopkins Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
[5] Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[6] Johns Hopkins Sch Med, Ctr Sensory Biol, Baltimore, MD 21205 USA
关键词
D O I
10.1038/nature05662
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sensory neurons innervating the skin encode the familiar sensations of temperature, touch and pain. An explosion of progress has revealed unanticipated cellular and molecular complexity in these senses. It is now clear that perception of a single stimulus, such as heat, requires several transduction mechanisms. Conversely, a given protein may contribute to multiple senses, such as heat and touch. Recent studies have also led to the surprising insight that skin cells might transduce temperature and touch. To break the code underlying somatosensation, we must therefore understand how the skin's sensory functions are divided among signalling molecules and cell types.
引用
收藏
页码:858 / 865
页数:8
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