Transient down-regulation of inhibin-beta C expression following partial hepatectomy

被引：35

作者：

Esquela, AF

Zimmers, RA

Koniaris, LG

Sitzmann, JV

Lee, SJ

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MOL BIOL & GENET,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV HOSP,DEPT SURG,BALTIMORE,MD 21205

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 235卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/bbrc.1997.6850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibin-beta C is a recently described TGF-beta family member most homologous to inhibin-beta A and inhibin-beta B. By Northern analysis, inhibin-beta C mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed, The expression of inhibin-beta C mRNA in adult liver dropped sharply and transiently following partial hepatectomy, At 6 and 12 hours following partial hepatectomy, the levels of inhibin-beta C mRNA were at least 8-fold lower than in control animals, The liver specificity of inhibin-beta C expression and its down-regulation following partial hepatectomy suggest that inhibin-beta C may function as a negative regulator of liver growth. (C) 1997 Academic Press.

引用

页码：553 / 556

页数：4

共 27 条

[1] TRANSFORMING GROWTH FACTOR-BETA MESSENGER-RNA INCREASES DURING LIVER-REGENERATION - A POSSIBLE PARACRINE MECHANISM OF GROWTH-REGULATION [J].