Detection of the PAX8-PPARγ fusion oncogene in both follicular thyroid carcinomas and adenomas
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作者:
Cheung, L
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机构:Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia
Cheung, L
Messina, M
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机构:Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia
Messina, M
Gill, A
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Gill, A
Clarkson, A
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Clarkson, A
Learoyd, D
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Learoyd, D
Delbridge, L
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Delbridge, L
Wentworth, J
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Wentworth, J
Philips, J
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Philips, J
Clifton-Bligh, R
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Clifton-Bligh, R
Robinson, BG
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Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, AustraliaRoyal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia
Robinson, BG
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机构:
[1] Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia
[2] Royal N Shore Hosp, Dept Surg, St Leonards, NSW 2065, Australia
[3] Royal N Shore Hosp, Dept Pathol, St Leonards, NSW 2065, Australia
Chromosomal translocations encoding fusion oncoproteins are common in hematological malignancies, sarcomas, and papillary thyroid carcinomas. A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferatoractivated receptor gamma (PPARgamma). Herein we report the detection of this putative oncoprotein in 6 of 17 (35%) follicular thyroid carcinomas as well as in 6 of 11 (55%) follicular thyroid adenomas. Concordant expression of protein was found in 91% of those tumors in which PAX8-PPARgamma mRNA was detected by RT-PCR, whereas a further 20% of follicular tumors were positive for PPARgamma immunohistochemistry alone. Our findings suggest that the PAX8-PPARgamma fusion protein promotes differentiated follicular thyroid neoplasia, although it is not sufficient per se for carcinogenesis.