Detection of the PAX8-PPARγ fusion oncogene in both follicular thyroid carcinomas and adenomas

被引:151
作者
Cheung, L
Messina, M
Gill, A
Clarkson, A
Learoyd, D
Delbridge, L
Wentworth, J
Philips, J
Clifton-Bligh, R
Robinson, BG [1 ]
机构
[1] Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia
[2] Royal N Shore Hosp, Dept Surg, St Leonards, NSW 2065, Australia
[3] Royal N Shore Hosp, Dept Pathol, St Leonards, NSW 2065, Australia
关键词
D O I
10.1210/jc.2002-021020
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chromosomal translocations encoding fusion oncoproteins are common in hematological malignancies, sarcomas, and papillary thyroid carcinomas. A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferatoractivated receptor gamma (PPARgamma). Herein we report the detection of this putative oncoprotein in 6 of 17 (35%) follicular thyroid carcinomas as well as in 6 of 11 (55%) follicular thyroid adenomas. Concordant expression of protein was found in 91% of those tumors in which PAX8-PPARgamma mRNA was detected by RT-PCR, whereas a further 20% of follicular tumors were positive for PPARgamma immunohistochemistry alone. Our findings suggest that the PAX8-PPARgamma fusion protein promotes differentiated follicular thyroid neoplasia, although it is not sufficient per se for carcinogenesis.
引用
收藏
页码:354 / 357
页数:4
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