Detection of the PAX8-PPARγ fusion oncogene in both follicular thyroid carcinomas and adenomas

被引：151

作者：

Cheung, L

Messina, M

Gill, A

Clarkson, A

Learoyd, D

Delbridge, L

Wentworth, J

Philips, J

Clifton-Bligh, R

Robinson, BG ^{[1
]}

机构：

[1] Royal N Shore Hosp, Kolling Inst Med Res, Canc Genet Unit, St Leonards, NSW 2065, Australia

[2] Royal N Shore Hosp, Dept Surg, St Leonards, NSW 2065, Australia

[3] Royal N Shore Hosp, Dept Pathol, St Leonards, NSW 2065, Australia

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2003年 / 88卷 / 01期

关键词：

D O I：

10.1210/jc.2002-021020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chromosomal translocations encoding fusion oncoproteins are common in hematological malignancies, sarcomas, and papillary thyroid carcinomas. A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferatoractivated receptor gamma (PPARgamma). Herein we report the detection of this putative oncoprotein in 6 of 17 (35%) follicular thyroid carcinomas as well as in 6 of 11 (55%) follicular thyroid adenomas. Concordant expression of protein was found in 91% of those tumors in which PAX8-PPARgamma mRNA was detected by RT-PCR, whereas a further 20% of follicular tumors were positive for PPARgamma immunohistochemistry alone. Our findings suggest that the PAX8-PPARgamma fusion protein promotes differentiated follicular thyroid neoplasia, although it is not sufficient per se for carcinogenesis.

引用

页码：354 / 357

页数：4

共 37 条

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