Treatment of murine disseminated candidiasis with L-743,872

被引：60

作者：

Graybill, JR ^{[1
]}

Najvar, LK ^{[1
]}

Luther, MF ^{[1
]}

Fothergill, AW ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 08期

关键词：

D O I：

10.1128/AAC.41.8.1775

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans, In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

引用

页码：1775 / 1777

页数：3

共 21 条

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