The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis

被引：44

作者：

Ariumi, H ^{[1
]}

Saito, R ^{[1
]}

Nago, S ^{[1
]}

Hyakusoku, M ^{[1
]}

Takano, Y ^{[1
]}

Kamiya, H ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8140180, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 286卷 / 02期

关键词：

emesis; area postrema; NK-1; antagonists; ferret; nucleus tractus solitarius;

D O I：

10.1016/S0304-3940(00)01113-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of tachykinin NK-1 receptors in the area postrema (AP) in emesis was examined in ferrets. Strong c-fos-like immunoreactivity was observed in the AP and nucleus tractus solitalius (NTS) in cisplatin (10 mg/kg, i.p.)-treated animals, but not in control animals. The number of the central emetogen morphine-induced vomits and retches was remarkably reduced (95%) and that of the peripheral emetogen copper sulphate-induced vomits was significantly (54%) reduced by AP lesion. Pretreatment with the tachykinin NK-1 receptor antagonists HSP-117 (1.0 mu g) and CP-99,984 (7.5 mu g) into the AP decreased the numbers of Vomits and retches induced by morphine and copper sulphate. These results suggest that NK-1 receptors in the AP are involved in the mechanism of emesis induced by morphine and copper sulphate. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：123 / 126

页数：4

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