A formal total synthesis of taxol aided by an automated synthesizer

被引：108

作者：

Doi, Takayuki ^{[1
]}

Fuse, Shinichiro ^{[1
]}

Miyamoto, Shigeru ^{[1
]}

Nakai, Kazuoki ^{[1
]}

Sasuga, Daisuke ^{[1
]}

Takahashi, Takashi ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2006年 / 1卷 / 03期

关键词：

antitumor agents; automated synthesis; natural products; synthetic methods; total synthesis;

D O I：

10.1002/asia.200600156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.

引用

页码：370 / 383

页数：14

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