Heart involvement in systemic sclerosis: Evolving concept and diagnostic methodologies

被引：114

作者：

Meune, Christophe ^{[1
]}

Vignaux, Olivier ^{[2
]}

Kahan, Andre ^{[3
]}

Allanore, Yannick ^{[3
]}

机构：

[1] Univ Paris 05, Hop Cochin, AP HP, Serv Cardiol, F-75014 Paris, France

[2] Paris Descartes Univ, Hop Cochin, AP HP, Dept Radiol A, F-75014 Paris, France

[3] Paris Descartes Univ, Hop Cochin, AP HP, Dept Rheumatol A, F-75014 Paris, France

来源：

ARCHIVES OF CARDIOVASCULAR DISEASES | 2010年 / 103卷 / 01期

关键词：

Myocardium; Ischaemia; Reperfusion; Natriuretic peptides; Tissue doppler echocardiography; PULMONARY ARTERIAL-HYPERTENSION; BRAIN NATRIURETIC PEPTIDE; DOPPLER-ECHOCARDIOGRAPHY; MYOCARDIAL-PERFUSION; CARDIAC INVOLVEMENT; SCLERODERMA; DYSFUNCTION; ABNORMALITIES; PREDICTORS; SURVIVAL;

D O I：

10.1016/j.acvd.2009.06.009

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Heart involvement, including primary myocardial involvement, is very common in systemic sclerosis. There is strong evidence that primary myocardial involvement is related to repeat focal ischaemic injury causing subsequent irreversible myocardial fibrosis. Clinically evident cardiac involvement is recognized to be a poor prognostic factor; thus preclinical identification is highly encouraged. The severity of heart involvement has been confirmed recently. Echocardiography, including pulsed tissue Doppler echocardiography, is the cornerstone of routine heart assessment. Myocardial perfusion may be assessed by single photon emission computed tomography. If available, cardiac magnetic resonance imaging should be considered as it allows simultaneous measurement of ventricular volumes and function and myocardial perfusion, and assessment of possible inflammation and/or fibrosis. Biological variables, such as B-type natriuretic peptides, are highly relevant, valuable markers of global heart involvement in systemic sclerosis and should be considered for screening of patients and/or research purposes. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：46 / 52

页数：7

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