Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: Case study

被引：33

作者：

Rojas-Marcos, Inigo

Graus, Francesc

Sanz, Gema

Robledo, Arturo

Diaz-Espejo, Carlos

机构：

[1] Hosp Juan Ramon Jimenez, Dept Neurol, Huelva 21005, Spain

[2] Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain

来源：

NEURO-ONCOLOGY | 2007年 / 9卷 / 01期

关键词：

anti-Ma2; antibodies; diencephalic encephalitis; excessive daytime sleepiness; hypersomnia; paraneoplastic syndrome;

D O I：

10.1215/15228517-2006-013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiber-bronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.

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收藏

页码：75 / 77

页数：3

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