LTP mechanisms: from silence to four-lane traffic

被引:316
作者
Malinow, R [1 ]
Mainen, ZF [1 ]
Hayashi, Y [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
关键词
D O I
10.1016/S0959-4388(00)00099-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example - long-term potentation in the CA1 region of the hippocampus - has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.
引用
收藏
页码:352 / 357
页数:6
相关论文
共 69 条
  • [21] Enhanced LTP in mice deficient in the AMPA receptor GluR2
    Jia, ZP
    Agopyan, N
    Miu, P
    Xiong, ZG
    Henderson, J
    Gerlai, R
    Taverna, FA
    Velumian, A
    MacDonald, J
    Carlen, P
    AbramowNewerly, W
    Roder, J
    [J]. NEURON, 1996, 17 (05) : 945 - 956
  • [22] A PERSISTENT POSTSYNAPTIC MODIFICATION MEDIATES LONG-TERM POTENTIATION IN THE HIPPOCAMPUS
    KAUER, JA
    MALENKA, RC
    NICOLL, RA
    [J]. NEURON, 1988, 1 (10) : 911 - 917
  • [23] Organization and regulation of proteins at synapses
    Kim, JH
    Huganir, RL
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) : 248 - 254
  • [24] Extrasynaptic glutamate spillover in the hippocampus: evidence and implications
    Kullmann, DM
    Asztely, F
    [J]. TRENDS IN NEUROSCIENCES, 1998, 21 (01) : 8 - 14
  • [25] THE SITE OF EXPRESSION OF NMDA RECEPTOR-DEPENDENT LTP - NEW FUEL FOR AN OLD FIRE
    KULLMANN, DM
    SIEGELBAUM, SA
    [J]. NEURON, 1995, 15 (05) : 997 - 1002
  • [26] LONG-TERM POTENTIATION IS ASSOCIATED WITH INCREASES IN QUANTAL CONTENT AND QUANTAL AMPLITUDE
    KULLMANN, DM
    NICOLL, RA
    [J]. NATURE, 1992, 357 (6375) : 240 - 244
  • [27] PRESYNAPTIC RELEASE PROBABILITY INFLUENCES THE LOCUS OF LONG-TERM POTENTIATION
    LARKMAN, A
    HANNAY, T
    STRATFORD, K
    JACK, J
    [J]. NATURE, 1992, 360 (6399) : 70 - 73
  • [28] SAP97 is associated with the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit
    Leonard, AS
    Davare, MA
    Horne, MC
    Garner, CC
    Hell, JW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (31) : 19518 - 19524
  • [29] Silent glutamatergic synapses and nociception in mammalian spinal cord
    Li, P
    Zhuo, M
    [J]. NATURE, 1998, 393 (6686) : 695 - 698
  • [30] DIRECT MEASUREMENT OF QUANTAL CHANGES UNDERLYING LONG-TERM POTENTIATION IN CA1 HIPPOCAMPUS
    LIAO, D
    JONES, A
    MALINOW, R
    [J]. NEURON, 1992, 9 (06) : 1089 - 1097