Role of sirtuin proteins in life extension by caloric restriction

被引：40

作者：

Masoro, EJ ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78229 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 09期

关键词：

sirtuin; caloric restriction; life extension;

D O I：

10.1016/j.mad.2004.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The deacetylase activity of sirtuin proteins may play a key role in the life extending action of caloric restriction in organisms ranging from yeast to mammals. Recent research has been focused on the possible afferent pathway by which caloric restriction increases the deacetylase activity and on the efferent pathway by which the increased deacetylase activity extends life. Further research is needed to firmly establish the role of sirtuin proteins in life extension by caloric restriction in mammals. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：591 / 594

页数：4

共 28 条

[1]

Anderson SP, 2000, INT J IND ORGAN, V18, P1

[2]

Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver [J].

Ando, K ;

Higami, Y ;

Tsuchiya, T ;

Kanematsu, T ;

Shimokawa, I .

MICROSCOPY RESEARCH AND TECHNIQUE, 2002, 59 (04) :293-300

[3]

BERG BN, 1960, J NUTR, V71, P255

[4]

CHANGES IN ADIPOSE MASS AND CELLULARITY THROUGH THE ADULT LIFE OF RATS FED AD-LIBITUM OR A LIFE-PROLONGING RESTRICTED DIET [J].

BERTRAND, HA ;

LYND, FT ;

MASORO, EJ ;

YU, BP .

JOURNALS OF GERONTOLOGY, 1980, 35 (06) :827-835

[5]

Extended longevity in mice lacking the insulin receptor in adipose tissue [J].

Blüher, M ;

Kahn, BB ;

Kahn, CR .

SCIENCE, 2003, 299 (5606) :572-574

[6]

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase [J].

Cohen, HY ;

Miller, C ;

Bitterman, KJ ;

Wall, NR ;

Hekking, B ;

Kessler, B ;

Howitz, KT ;

Gorospe, M ;

de Cabo, R ;

Sinclair, DA .

SCIENCE, 2004, 305 (5682) :390-392

[7]

Dirkswager Edward J, 2002, Caloric restriction: A key to understanding and modulating aging

[8]

FOOD RESTRICTION ELIMINATES PRENEOPLASTIC CELLS THROUGH APOPTOSIS AND ANTAGONIZES CARCINOGENESIS IN RAT-LIVER [J].

GRASLKRAUPP, B ;

BURSCH, W ;

RUTTKAYNEDECKY, B ;

WAGNER, A ;

LAUER, B ;

SCHULTEHERMANN, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9995-9999

[9]

Genetic pathways that regulate ageing in model organisms [J].

Guarente, L ;

Kenyon, C .

NATURE, 2000, 408 (6809) :255-262

[10]

EFFECTS OF FOOD RESTRICTION ON AGING - SEPARATION OF FOOD-INTAKE AND ADIPOSITY [J].

HARRISON, DE ;

ARCHER, JR ;

ASTLE, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (06) :1835-1838

← 1 2 3 →