Total synthesis of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

被引：69

作者：

Murakami, N ^{[1
]}

Wang, WQ ^{[1
]}

Aoki, M ^{[1
]}

Tsutsui, Y ^{[1
]}

Sugimoto, M ^{[1
]}

Kobayashi, M ^{[1
]}

机构：

[1] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 565, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(98)00151-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A first total synthesis of callystatin A (1), a potent cytotoxic polyketide from the marine sponge Callyspongia truncata, has been achieved by use of an E-selective Wittig olefination and asymmetric Evans aldol condensation as the key reactions. Thus, the absolute stereostructure of 1 previously established by us was confirmed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2349 / 2352

页数：4

共 9 条

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