Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii

被引：21

作者：

Kanaujia, Anil ^{[1
]}

Duggar, Rajeev ^{[1
]}

Pannakal, Steve Thomas ^{[1
]}

Yadav, Satyapal Singh ^{[1
]}

Katiyar, Chandra Kant ^{[1
]}

Bansal, Vinay ^{[1
]}

Anand, S. ^{[2
]}

Sujatha, S. ^{[2
]}

Lakshmi, B. S. ^{[2
]}

机构：

[1] Ranbaxy Res Labs, New Drug Discovery Res, R&D 3, Udyog Vihar Ind Area, Gurgaon, Haryana, India

[2] Anna Univ, Ctr Biotechnol, Chennai 600025, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 11期

关键词：

Capparis moonii; Gallotannins; Glucose uptake; HYDROLYZABLE TANNINS; PLANT;

D O I：

10.1016/j.bmc.2010.04.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10 ng/ml and 100 ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3940 / 3945

页数：6

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