Fischer indolization of 2-sulfonyloxyphenylhydrazones: A new and practical approach for preparing 7-oxygenated indoles and application to the first synthesis of eudistomidin-A (Fischer indolization and its related compounds, Part 28)

被引：25

作者：

Murakami, Y

Watanabe, T

Takahashi, H

Yokoo, H

Nakazawa, Y

Koshimizu, H

Adachi, N

Kurita, M

Yoshino, T

Inagaki, T

Ohishi, M

Watanabe, M

Tani, M

Yokoyama, Y

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 274, Japan

[2] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 263, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 1-2期

关键词：

D O I：

10.1016/S0040-4020(97)10255-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for synthesis of 7-oxygenated indoles was established by Fischer indolization of the phenylhydrazones (10) with a sulfonyloxy group at the ortho-position. This method was applied to the first synthesis of the calmodulin antagonist eudistomidin-A (2). (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：45 / 64

页数：20

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