Synthesis of C-19-functionalized 1α-hydroxyvitamin D2 analogues via ring-closing metathesis

被引：28

作者：

Ahmed, M

Atkinson, CE

Barrett, AGM ^{[1
]}

Malagu, K

Procopiou, PA

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] GlaxoSmithKline, Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1021/ol027406w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A heteroatom-tethered regloselective ring-closing metathesis reaction was used for the C-19 functionalization of 1alpha-hydroxy-5,6-trans-vitamin D-2 analogues. Applications of the reaction to form a range of analogues by manipulation of the tether using both organolithium reagents and Diels-Alder cycloadditions are described.

引用

页码：669 / 672

页数：4

共 24 条

[1] Synthesis and binding-analysis of 5E-[19-(2-bromoacetoxy)methyl]25-hydroxyvitamin D3 and 5E-25-hydroxyvitamin D3-19-methyl[(4-azido-2-nitro)phenyl]glycinate:: Novel C19-modified affinity and photoaffinity analogs of 25-hydroxyvitamin D3 [J].