Microorganisms in the aetiology of atherosclerosis

被引:43
作者
Morré, SA
Stooker, W
Lagrand, WK
van den Brule, AJC
Niessen, HWM
机构
[1] Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands
[2] Free Univ Amsterdam Hosp, Dept Cardiac Surg, Amsterdam, Netherlands
[3] Free Univ Amsterdam Hosp, Dept Cardiol, Amsterdam, Netherlands
关键词
atherosclerosis; Chlamydia pneumoniae; Helicobacter pylori;
D O I
10.1136/jcp.53.9.647
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Recent publications have suggested that infective pathogens might play an important role in the pathogenesis of atherosclerosis. This review focuses on these microorganisms in the process of atherosclerosis. The results of in vitro studies, animal studies, tissue studies, and serological studies will be summarised, followed by an overall conclusion concerning the strength of the association of the microorganism with the pathogenesis of atherosclerosis. The role of the bacteria Chlamydia pneumoniac and Helicobacter pylori, and the viruses human immunodeficiency virus, coxsackie B virus, cytomegalovirus, Epstein-Barr virus, herpes simplex virus, and measles virus will be discussed.
引用
收藏
页码:647 / 654
页数:8
相关论文
共 116 条
[41]   Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen [J].
Jackson, LA ;
Campbell, LA ;
Kuo, CC ;
Rodriguez, DI ;
Lee, A ;
Grayston, JT .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (01) :292-295
[42]  
Jacob H S, 1992, Trans Am Clin Climatol Assoc, V103, P95
[43]   Inflammation in high-grade carotid stenosis - A possible role for macrophages and T cells in plaque destabilization [J].
Jander, S ;
Sitzer, M ;
Schumann, R ;
Schroeter, M ;
Siebler, M ;
Steinmetz, H ;
Stoll, G .
STROKE, 1998, 29 (08) :1625-1630
[44]   Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms [J].
Juvonen, JJ ;
Tuvonen, T ;
Laurila, A ;
Alakarppa, H ;
Lounatmaa, K ;
Surcel, HM ;
Leinonen, M ;
Kairaluoma, MI ;
Saikku, P .
JOURNAL OF VASCULAR SURGERY, 1997, 25 (03) :499-505
[45]   A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide [J].
Kalayoglu, MV ;
Byrne, GI .
INFECTION AND IMMUNITY, 1998, 66 (11) :5067-5072
[46]   Induction of macrophage foam cell formation by Chlamydia pneumoniae [J].
Kalayoglu, MV ;
Byrne, GI .
JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (03) :725-729
[47]   DEVELOPMENTALLY-REGULATED HERPESVIRUS PLAQUE-FORMATION IN ARTERIAL SMOOTH-MUSCLE CELLS [J].
KANER, RJ ;
MEDINA, J ;
NICHOLSON, AC ;
URSEA, R ;
SCHWARTZ, SM ;
HAJJAR, DP .
CIRCULATION RESEARCH, 1993, 73 (01) :10-14
[48]   INFECTION OF VASCULAR ENDOTHELIAL-CELLS WITH HERPES-SIMPLEX VIRUS ENHANCES TISSUE FACTOR ACTIVITY AND REDUCES THROMBOMODULIN EXPRESSION [J].
KEY, NS ;
VERCELLOTTI, GM ;
WINKELMANN, JC ;
MOLDOW, CF ;
GOODMAN, JL ;
ESMON, NL ;
ESMON, CT ;
JACOB, HS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7095-7099
[49]  
KEY NS, 1993, LAB INVEST, V68, P645
[50]   Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-α and matrix metalloproteinase expression [J].
Kol, A ;
Sukhova, GK ;
Lichtman, AH ;
Libby, P .
CIRCULATION, 1998, 98 (04) :300-307