Crosslinks and crosstalk: Human cancer syndromes and DNA repair defects

被引：27

作者：

Risinger, MA ^{[1
]}

Groden, J ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA

来源：

CANCER CELL | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2004.12.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A subset of human cancer syndromes result from inherited defects in genes responsible for DNA repair. During the past few years, discoveries concerning the intersection of certain DNA repair processes have increased our understanding of how the disruption of specific DNA repair mechanisms leads to genomic instability and tumorigenesis. This review focuses on the human genes MUTYH, BRCA2/FANCD1, and BLM.

引用

页码：539 / 545

页数：7

共 71 条

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