Regulation of CXCR4 signaling

被引：487

作者：

Busillo, John M. ^{[1
]}

Benovic, Jeffrey L. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2007年 / 1768卷 / 04期

关键词：

CXCR4; receptor regulation; phosphorylation; cancer; WHIM syndrome; signaling;

D O I：

10.1016/j.bbamem.2006.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：952 / 963

页数：12

共 181 条

[1] Role for CCR5Δ32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type 1 in primary CD4+ cells [J].

Agrawal, L ;

Lu, XH ;

Qingwen, J ;

VanHorn-Ali, Z ;

Nicolescu, IV ;

McDermott, DH ;

Murphy, PM ;

Alkhatib, G .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2277-2287

[2] Anti-HIV therapy: Current and future directions [J].

Agrawal, Lokesh ;

Lu, Xihua ;

Jin, Qingwen ;

Alkhatib, Ghalib .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (16) :2031-2055

[3] Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by β-arrestins 1 and 2 [J].

Ahn, S ;

Wei, HJ ;

Garrison, TR ;

Lefkowitz, RJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) :7807-7811

[4] Molecular characterization of the tumor microenvironment in breast cancer [J].

Allinen, M ;

Beroukhim, R ;

Cai, L ;

Brennan, C ;

Lahti-Domenici, J ;

Huang, HY ;

Porter, D ;

Hu, M ;

Chin, L ;

Richardson, A ;

Schnitt, S ;

Sellers, WR ;

Polyak, K .

CANCER CELL, 2004, 6 (01) :17-32

[5] Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function [J].

Angers, S ;

Salahpour, A ;

Bouvier, M .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2002, 42 :409-435

[6] A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo [J].

Ara, T ;

Itoi, M ;

Kawabata, K ;

Egawa, T ;

Tokoyoda, K ;

Sugiyama, T ;

Fujii, N ;

Amagai, T ;

Nagasawa, T .

JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4649-4655

[7] Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor [J].

Babcock, GJ ;

Farzan, M ;

Sodroski, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (05) :3378-3385

[8]

Bachelder RE, 2002, CANCER RES, V62, P7203

[9] WHIM4 syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12 [J].

Balabanian, K ;

Lagane, B ;

Pablos, JL ;

Laurent, L ;

Planchenault, T ;

Verola, O ;

Lebbe, C ;

Kerob, D ;

Dupuy, A ;

Hermine, O ;

Nicolas, JF ;

Latger-Cannard, W ;

Bensoussan, D ;

Bordigoni, P ;

Baleux, F ;

Le Deist, F ;

Virelizier, JL ;

Arenzana-Seisdedos, F ;

Bachelerie, F .

BLOOD, 2005, 105 (06) :2449-2457

[10] The significance of cancer cell expression of the chemokine receptor CXCR4 [J].

Balkwill, F .

SEMINARS IN CANCER BIOLOGY, 2004, 14 (03) :171-179

← 1 2 3 4 5 6 7 8 9 10 →