Electrophysiological classes of cat primary visual cortical neurons in vivo as revealed by quantitative analyses

被引:282
作者
Nowak, LG
Azouz, R
Sanchez-Vives, MV
Gray, CM
McCormick, DA
机构
[1] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
[2] Univ Toulouse 3, CNRS, UMR 5549, Unite Rech Cerveau & Cognit, F-31062 Toulouse, France
[3] Montana State Univ, Ctr Computat Biol, Bozeman, MT 59717 USA
[4] Univ Miguel Hernandez, Consejo Super Invest, Inst Neurociencias, San Juan De Alicante, Spain
关键词
D O I
10.1152/jn.00580.2002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To facilitate the characterization of cortical neuronal function, the responses of cells in cat area 17 to intracellular injection of current pulses were quantitatively analyzed. A variety of response variables were used to separate the cells into subtypes using cluster analysis. Four main classes of neurons could be clearly distinguished: regular spiking (RS), fast spiking (FS), intrinsic bursting (IB), and chattering (CH). Each of these contained significant subclasses. RS neurons were characterized by trains of action potentials that exhibited spike frequency adaptation. Morphologically, these cells were spiny stellate cells in layer 4 and pyramidal cells in layers 2, 3, 5, and 6. FS neurons had short-duration action potentials (<0.5 ms at half height), little or no spike frequency adaptation, and a steep relationship between injected current intensity and spike discharge frequency. Morphologically, these cells were sparsely spiny or aspiny nonpyramidal cells. IB neurons typically generated a low frequency (<425 Hz) burst of spikes at the beginning of a depolarizing current pulse followed by a tonic train of action potentials for the remainder of the pulse. These cells were observed in all cortical layers, but were most abundant in layer 5. Finally, CH neurons generated repetitive, high-frequency (350-700 Hz) bursts of short-duration (<0.55 ms) action potentials. Morphologically, these cells were layer 2-4 (mainly layer 3) pyramidal or spiny stellate neurons. These results indicate that firing properties do not form a continuum and that cortical neurons are members of distinct electrophysiological classes and subclasses.
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页码:1541 / 1566
页数:26
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