Cellular distribution and functions of P2 receptor subtypes in different systems

被引：606

作者：

Burnstock, G ^{[1
]}

Knight, GE ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Inst, London NW3 2PF, England

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL. 240 | 2004年 / 240卷

关键词：

purinergic; P2X; P2Y; plasticity; neuron; smooth muscle; epithelium; endothelium;

D O I：

10.1016/S0074-7696(04)40002-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each section provides an account of the early history of purinergic signaling in the organ/cell up to 1994, then summarizes subsequent evidence for the presence of P2X and P2Y receptor subtype mRNA and proteins as well as functional data, all fully referenced. A section is included describing the plasticity of expression of P2 receptors during development and aging as well as in various pathophysiological conditions. Finally, there is some discussion of possible future developments in the purinergic signaling field.

引用

页码：31 / +

页数：89

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