Intravenous vasoactive intestinal polypeptide lowers pulmonary-to-systemic vascular resistance ratio in a neonatal piglet model of pulmonary arterial hypertension

被引：10

作者：

Haydar, Sam ^{[1
]}

Sarti, J. Fernando

Grisoni, Enrique R.

机构：

[1] Banner Childrens Hosp, Banner Desert Med Ctr, Dept Surg, Mesa, AZ 85202 USA

[2] St Josephs Hosp, Phoenix, AZ 85013 USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2007年 / 42卷 / 05期

关键词：

pulmonary arterial hypertension; vasoactive intestinal polypeptide; meconium aspiration syndrome;

D O I：

10.1016/j.jpedsurg.2006.12.026

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Several studies of vasoactive intestinal polypeptide (VIP) demonstrated its Potent vasodilative effects on pulmonary and systemic circulation. However, no hemodynamic studies were performed to depict the effects of VIP in an in vivo model of pulmonary arterial hypertension (PAH), thereby limiting a complete understanding of the overall hemodynamic effects of VIP in PAH. Methods and Results: The pulmonary and systemic hemodynamic effects of intravenous infusion of 100 ng/kg per minute of VIP in control and pulmonary hypertensive piglets at 6 to 8 weeks of age were assessed. Pulmonary arterial hypertension was induced after the instillation of meconium solution in the subjects' trachea and was characterized by the establishment of a persistently elevated pulmonary arterial pressure, diminished cardiac output, and elevated pulmonary-to-systemic vascular resistance (PVR/SVR) ratio. Conclusions: Continuous intravenous infusion of VIP markedly decreased PVR/SVR ratio in pulmonary hypertensive subjects; however, it lowered blood pressure without causing any significant changes in PVR/SVR ratio in control subjects. Collectively, these results suggest an overall pulmonary vasodilative effect of VIP in PAH. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：758 / 764

页数：7

共 38 条

[11] COMPARATIVE-STUDY OF VASCULAR RELAXATION AND RECEPTOR-BINDING BY PACAP AND VIP [J].

HUANG, M ;

SHIRAHASE, H ;

RORSTAD, OP .

PEPTIDES, 1993, 14 (04) :755-762

[12]

*I LAB AN RES, 1996, GUID CAR US LAB AN, P28

[13] Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension [J].

Ichinose, F ;

Erana-Garcia, J ;

Hromi, J ;

Raveh, Y ;

Jones, R ;

Krim, L ;

Clark, MWH ;

Winkler, JD ;

Bloch, KD ;

Zapol, WM .

CRITICAL CARE MEDICINE, 2001, 29 (05) :1000-1005

[14]

Iwabuchi S, 1997, RESPIRATION, V64, P54

[15] Statistical analyses of repeated measures in physiological research: a tutorial [J].

Kristensen, M ;

Hansen, T .

ADVANCES IN PHYSIOLOGY EDUCATION, 2004, 28 (01) :2-14

[16] LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) TO CENTRAL AND PERIPHERAL NEURONS [J].

LARSSON, LI ;

FAHRENKRUG, J ;

MUCKADELL, OSD ;

SUNDLER, F ;

HAKANSON, R ;

REHFELD, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (09) :3197-3200

[17] STRUCTURE AND EXPRESSION OF THE GENE ENCODING THE VASOACTIVE-INTESTINAL-PEPTIDE PRECURSOR [J].

LINDER, S ;

BARKHEM, T ;

NORBERG, A ;

PERSSON, H ;

SCHALLING, M ;

HOKFELT, T ;

MAGNUSSON, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :605-609

[18]

LUNDBERG JM, 1979, GASTROENTEROLOGY, V77, P468

[19] INNERVATION OF LOWER AIRWAYS AND NEUROPEPTIDE EFFECTS ON BRONCHIAL AND VASCULAR TONE IN THE PIG [J].

MARTLING, CR ;

MATRAN, R ;

ALVING, K ;

HOKFELT, T ;

LUNDBERG, JM .

CELL AND TISSUE RESEARCH, 1990, 260 (02) :223-233

[20] Survival with first-line bosentan in patients with primary pulmonary hypertension [J].

McLaughlin, VV ;

Sitbon, O ;

Badesch, DB ;

Barst, RJ ;

Black, C ;

Gallè, N ;

Rainisio, M ;

Simonneau, G ;

Rubin, LJ .

EUROPEAN RESPIRATORY JOURNAL, 2005, 25 (02) :244-249

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