An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells

被引：38

作者：

Lindemann, Stephen R. ^{[1
]}

McLendon, Molly K. ^{[1
]}

Apicella, Michael A. ^{[1
]}

Jones, Bradley D. ^{[1
]}

机构：

[1] Univ Iowa, Sch Med, Dept Microbiol, Iowa City, IA 52242 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 06期

关键词：

D O I：

10.1128/IAI.01811-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In observing Francisella tularensis interactions with nonphagocytic cell lines in vitro, we noted significant adherence, invasion, and intracellular growth of the bacteria within these cells. F. tularensis live vaccine strain invasion of nonprofessional phagocytic cells is inhibited by cytochalasin D and nocodazole, suggesting that both the actin and microtubule cytoskeletons are important for invasion.

引用

页码：3178 / 3182

页数：5

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