The transcriptional code of human IFN-β gene expression

被引：83

作者：

Ford, Ethan ^{[1
]}

Thanos, Dimitris ^{[1
]}

机构：

[1] Acad Athens, Inst Mol Biol Genet & Biotechnol, Biomed Res Fdn, Athens 11527, Greece

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 3-4期

关键词：

Chromatin; Transcription; Enhanceosome; Interferon-beta; NF-kappa B; IRF-3; NF-KAPPA-B; RNA-POLYMERASE-II; CRYSTAL-STRUCTURE; VIRUS INDUCTION; DNA-BINDING; HMG I(Y); COOPERATIVE BINDING; HISTONE VARIANTS; NUCLEAR FACTOR; ACTIVE GENES;

D O I：

10.1016/j.bbagrm.2010.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Activation of interferon-beta transcription is a highly ordered process beginning with the delivery of NF-kappa B to the IFN-beta enhancer through a process involving stochastic interchromosomal interactions between the IFN-beta enhancer and specialized Alu elements. NF-kappa B delivery is followed by the binding of ATF-2/c-Jun and IRF proteins in a highly cooperative fashion. The assembled "enhanceosome" then recruits PCAF/GCN5 which acetylates the histone tails of the adjacent nucleosomes. The transcriptional coactivator CBP, which binds in a complex with the RNA polymerase II holoenzyme is recruited by the enhanceosome replacing PCAF/GCN5. Next, SWI/SNF, which is part of the holoenzyme complex, induces a conformational change in a nucleosome positioned over the transcriptional start site allowing TFIID to bind, which promotes the sliding of this nucleosome to a new downstream position. At this point the full pre-initiation complex is assembled and transcription commences. This detailed picture of the IFN-beta transcription program gathered through years of rigorous studies, now serves as a paradigm for understanding complex transcriptional switches in eukaryotic systems. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：328 / 336

页数：9

共 93 条

[1]

Deciphering the transcriptional histone acetylation code for a human gene [J].

Agalioti, T ;

Chen, GY ;

Thanos, D .

CELL, 2002, 111 (03) :381-392

[2]

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[3]

Epigenetic determination of a cell-specific gene expression program by ATF-2 and the histone variant macroH2A [J].

Agelopoulos, Marios ;

Thanos, Dimitris .

EMBO JOURNAL, 2006, 25 (20) :4843-4853

[4]

The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of MacroH2A [J].

Allen, MD ;

Buckle, AM ;

Cordell, SC ;

Löwe, J ;

Bycroft, M .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 330 (03) :503-511

[5]

Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression [J].

Apostolou, Effie ;

Thanos, Dimitris .

CELL, 2008, 134 (01) :85-96

[6]

Eukaryotic gene regulation in three dimensions and its impact on genome evolution [J].

Babu, M. Madan ;

Janga, Sarath Chandra ;

de Santiago, Ines ;

Pombo, Ana .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (06) :571-582

[7]

The x-ray crystal structure of the NF-κB p50•p65 heterodimer bound to the interferon β-κB site [J].

Berkowitz, B ;

Huang, DB ;

Chen-Park, FE ;

Sigler, PB ;

Ghosh, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :24694-24700

[8]

MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF [J].

Chang, Evelyn Y. ;

Ferreira, Helder ;

Somers, Joanna ;

Nusinow, Dmitri A. ;

Owen-Hughes, Tom ;

Narlikar, Geeta J. .

BIOCHEMISTRY, 2008, 47 (51) :13726-13732

[9]

macroH2A1 histone variants are depleted on active genes but concentrated on the inactive X chromosome [J].

Changolkar, Lakshmi N. ;

Pehrson, John R. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (12) :4410-4420

[10]

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity [J].

Chinenov, Y ;

Kerppola, TK .

ONCOGENE, 2001, 20 (19) :2438-2452

← 1 2 3 4 5 6 7 8 9 10 →