Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat

被引：76

作者：

Jiang, Wenli ^{[1
,2
]}

Wang, Yuexiang ^{[1
]}

Tang, Jie ^{[1
]}

Peng, Jiang ^{[3
]}

Wang, Yu ^{[3
]}

Guo, Quanyi ^{[3
]}

Guo, Zhiyuan ^{[3
]}

Li, Pan ^{[3
]}

Xiao, Bo ^{[3
]}

Zhang, Jinxing ^{[3
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Ultrasound, 28 Fuxing Rd, Beijing 100853, Peoples R China

[2] Beijing Hosp, Dept Ultrasound, 1 Dahua Rd, Beijing 100730, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Chinese Peoples Liberat Army, Orthoped Res Inst, 28 Fuxing Rd, Beijing 100853, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

GLYCOLIC ACID) CONDUITS; SCIATIC-NERVE; DIFFERENTIATION; REPAIR; STEM; ULTRASONOGRAPHY; TUBULIZATION; STIMULATION; GROWTH; LIPUS;

D O I：

10.1038/srep22773

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Low intensity pulsed ultrasound (LIPUS) has been widely used in clinic for the treatment of repairing pseudarthrosis, bone fractures and of healing in various soft tissues. Some reports indicated that LIPUS accelerated peripheral nerve regeneration including Schwann cells (SCs) and injured nerves. But little is known about its appropriate intensities on autograft nerves. This study was to investigate which intensity of LIPUS improved the regeneration of gold standard postsurgical nerves in experimental rat model. Sprague-Dawley rats were made into 10 mm right side sciatic nerve reversed autologous nerve transplantation and randomly treated with 250 mW/cm(2), 500 mW/cm(2) or 750 mW/cm(2) LIPUS for 2-12 weeks after operation. Functional and pathological results showed that LIPUS of 250 mW/cm(2) significantly induced faster rate of axonal regeneration. This suggested that autograft nerve regeneration was improved.

引用

页数：13

共 34 条

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