Lung inflammation as a therapeutic target in cystic fibrosis

被引：89

作者：

Koehler, DR

Downey, GP

Sweezey, NB

Tanswell, AK

Hu, J

机构：

[1] Hosp Sick Children, Programme Lung Biol Res, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Canadian Inst Hlth Res Grp Lung Dev, Toronto, ON M5G 1X8, Canada

[3] Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

[5] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[6] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[7] Univ Toronto, Dept Lab Med, Toronto, ON, Canada

[8] Univ Toronto, Dept Pathobiol, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2004年 / 31卷 / 04期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1165/rcmb.2004-0124TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cystic fibrosis (CF) lung disease is characterized by chronic neutrophilic inflammation and infection. Effective management of airway inflammation could complement other therapies for the treatment of CF. Recent progress has been made in understanding the signaling pathways regulating inflammatory cytokines in the lung. Here we examine the mechanisms responsible for inflammation in the CF lung, and discuss potential therapeutic strategies targeting inflammation.

引用

页码：377 / 381

页数：5