The endocannabinoid system and neurogenesis in health and disease

被引:85
作者
Galve-Roperh, Ismael [1 ]
Aguado, Tania [1 ]
Palazuelos, Javier [1 ]
Guzman, Manuel [1 ]
机构
[1] Univ Complutense, Sch Biol, Dept Biochem & Mol Biol 1, E-28040 Madrid, Spain
关键词
cannabinoids; neurogenesis; neural progenitors; brain diseases;
D O I
10.1177/1073858406296407
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The endocannabinoid system exerts an important neuromodulatory function in different brain areas and is also known to be involved in the regulation of neural cell fate. Thus, CB1 cannabinoid receptors are neuroprotective in different models of brain injury, and their expression is altered in various neurodegenerative diseases. Recent findings have demonstrated the presence of a functional endocannabinoid system in neural progenitor cells that participates in the regulation of cell proliferation and differentiation. In this Research Update, the authors address the experimental evidence regarding the regulatory role of cannabinoids in neurogenesis and analyze them in the context of those pathological disorders in which cannabinoid function and altered neuronal or glial generation is most relevant, for example, stroke and multiple sclerosis.
引用
收藏
页码:109 / 114
页数:6
相关论文
共 30 条
[1]   The endocannabinoid system drives neural progenitor proliferation [J].
Aguado, T ;
Monory, K ;
Palazuelos, J ;
Stella, N ;
Cravatt, B ;
Lutz, B ;
Marsicano, G ;
Kokaia, Z ;
Guzmán, M ;
Galve-Roperh, I .
FASEB JOURNAL, 2005, 19 (09) :1704-+
[2]   The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells [J].
Aguado, T ;
Palazuelos, J ;
Monory, K ;
Stella, N ;
Cravatt, B ;
Lutz, B ;
Marsicano, G ;
Kokaia, Z ;
Guzmán, M ;
Galve-Roperh, I .
JOURNAL OF NEUROSCIENCE, 2006, 26 (05) :1551-1561
[3]  
Arévalo-Martin A, 2003, J NEUROSCI, V23, P2511
[4]   Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor [J].
Berghuis, P ;
Dobszay, MB ;
Wang, XY ;
Spano, S ;
Ledda, F ;
Sousa, KM ;
Schulte, G ;
Ernfors, P ;
Mackie, K ;
Paratcha, G ;
Hurd, YL ;
Harkany, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :19115-19120
[5]   Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors [J].
Bilkei-Gorzo, A ;
Racz, I ;
Valverde, O ;
Otto, M ;
Michel, K ;
Sarstre, M ;
Zimmer, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) :15670-15675
[6]   Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212 [J].
Croxford, JL ;
Miller, SD .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (08) :1231-1240
[7]   A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain [J].
Curtis, MA ;
Faull, RLM ;
Glass, M .
JOURNAL OF CHEMICAL NEUROANATOMY, 2006, 31 (03) :210-215
[8]   The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells [J].
Eljaschewitsch, E ;
Witting, A ;
Mawrin, C ;
Lee, T ;
Schmidt, PM ;
Wolf, S ;
Hoertnagl, H ;
Raine, CS ;
Schneider-Stock, R ;
Nitsch, R ;
Ullrich, O .
NEURON, 2006, 49 (01) :67-79
[9]   The endogenous cannabinoid system and brain development [J].
Fernández-Ruiz, J ;
Berrendero, F ;
Hernáandez, ML ;
Ramos, JA .
TRENDS IN NEUROSCIENCES, 2000, 23 (01) :14-20
[10]   Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors [J].
Glass, M ;
Van Dellen, A ;
Blakemore, C ;
Hannan, AJ ;
Faull, RLM .
NEUROSCIENCE, 2004, 123 (01) :207-212