Wave2 activates serum response element via its VCA region and functions downstream of Rac

被引：3

作者：

Ishiguro, K

Cao, ZF

Lopez-Ilasca, M

Ando, T

Xavier, R

机构：

[1] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[2] Nagoya Univ, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[4] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2004年 / 301卷 / 02期

关键词：

signal transduction; serum response element; actin polymerization; rho GTPase; WAVE;

D O I：

10.1016/j.yexcr.2004.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

WAVE2 is a member of the WASP/WAVE family of protein effectors of actin reorganization and cell movement. In this report, we demonstrate that WAVE2 overexpression induces serum response element (SRE) activation through serum response factor. A WAVE2 mutant lacking the VCA region did not induce SIZE activation and actin polymerization. WAVE2-induced SRE activation was blocked by exposure of cells to Latrunculin A, or overexpression of actin mutant R62D. The DeltaVCA mutant inhibited Rae V12-induced SRE activation, suggesting that WAVE2 lies downstream of Rac. Similar deletion of the VCA domain of WASP attenuated Cdc42 V12-mediated SIZE activation, suggesting that WAVE2 acts in relation to Rae as WASP acts in relation to Cdc42. WAVE2 overexpression did not activate NF-kappaB. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：331 / 337

页数：7