Pharmacogenomics in cardiovascular medicine

被引：2

作者：

Carlquist, JF ^{[1
]}

Anderson, JL ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Salt Lake City, UT USA

来源：

DRUG DEVELOPMENT RESEARCH | 2004年 / 62卷 / 03期

关键词：

pharmacogenomics; cardiovascular drugs; single nucleotide polymorphisms;

D O I：

10.1002/ddr.10355

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The completion of the Human Genome Project (HGP) holds promise for further insight into how genetic differences contribute to an individual's response to a medicine(s). Even before the completion of the HGP, cardiovascular medicine was thrust into the arena of pharmacogenomics by the observation that many drugs, cardiovascular and noncardiovascular, promote cardiac arrhythmias. It is now recognized that these adverse responses as well as beneficial responses to cardiovascular medicines can be influenced by alterations in the genes for metabolizing enzymes, drug transporters, and drug targets. To the present, much basic information regarding gene-drug interactions has accumulated, but translation to clinical care has been slow. It is anticipated that the pace of clinical cardiovascular pharmacogenomics will increase as the result of better-designed studies and technological advances. The final adoption of this area of investigation into clinical practice will also be influenced by financial, psychosocial, and legal factors. (C) 2004 Wiley-Liss, Inc.

引用

页码：180 / 190

页数：11

共 80 条

[71] A pharmacogenetic approach to blood pressure in Lyon hypertensive rats - A chromosome 2 locus influences the response to a calcium antagonist [J].