Effects of mupirocin at subinhibitory concentrations on flagella formation in Pseudomonas aeruginosa and Proteus mirabilis

被引：25

作者：

Horii, T

Morita, M

Muramatsu, H

Muranaka, Y

Kanno, T

Maekawa, M

机构：

[1] Hamamatsu Univ Sch Med, Dept Lab Med, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ Sch Med, Grp Infect Control Res, Hamamatsu, Shizuoka 4313192, Japan

[3] Hamamatsu Univ Sch Med, Div Pharm, Hamamatsu, Shizuoka 4313192, Japan

[4] Hamamatsu Univ Sch Med, Lab Ultrastruct Res, Hamamatsu, Shizuoka 4313192, Japan

[5] Daiichi Pure Chem, Ryugasaki 3010852, Japan

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 05期

关键词：

D O I：

10.1093/jac/dkg226

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Colonization of Pseudomonas aeruginosa at trachea, nares and oropharynx can cause ventilator-acquired pneumonia. To identify beneficial effects of antibiotics on expression of virulence factors related to colonization by such pathogens, we evaluated the effect of mupirocin on flagella formation in P. aeruginosa and on motility and flagella formation in Proteus mirabilis. In P. aeruginosa, subinhibitory concentrations of mupirocin inhibited flagella formation, which was associated with reduced flagellin expression. In A mirabilis, subinhibitory concentrations of mupirocin dose-dependently suppressed bacterial motility and flagella formation, again with reduced flagellin expression. Our results indicate that subinhibitory concentrations of mupirocin can suppress expression of virulence factors in A aeruginosa and A mirabilis.

引用

页码：1175 / 1179

页数：5

共 24 条

[1] Use of the polymerase chain reaction for rapid detection of high-level mupirocin resistance in staphylococci [J].