Uniform Beads with Controllable Pore Sizes for Biomedical Applications

被引：71

作者：

Choi, Sung-Wook ^{[1
]}

Yeh, Yi-Chun ^{[1
,2
]}

Zhang, Yu ^{[1
]}

Sung, Hsing-Wen ^{[2
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu, Taiwan

来源：

SMALL | 2010年 / 6卷 / 14期

关键词：

biomedicine; cells; emulsions; phase separation; porous beads; IN-VITRO; HEPATOCYTE SPHEROIDS; MASS-TRANSFER; TISSUE; MICROSPHERES; MICROCARRIERS; COMPOSITE; CARTILAGE; CARRIERS; SCAFFOLD;

D O I：

10.1002/smll.201000544

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Uniform beads of poly(D,L-lactide-co- glycolide) with small or large pores are fabricated by selectively introducing phase-separated layers of an unstable emulsion into a fluidic device using a syringe with a tip offset from the barrel. When fibroblasts are cultured in the beads, a higher density of viable cells occurs in the beads with larger pores. These beads could be useful for tissue engineering and cell-delivery applications.

引用

页码：1492 / 1498

页数：7