The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline

被引：13

作者：

Baldwin, JE ^{[1
]}

Pritchard, GJ ^{[1
]}

Williamson, DS ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(00)00352-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools ibr neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel Fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarboxylmethy-4-methanesulfonyloxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1927 / 1929

页数：3

共 16 条

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