Import of nuclear-encoded proteins into mitochondria

被引：53

作者：

Stojanovski, D ^{[1
]}

Johnston, AJ ^{[1
]}

Streimann, I ^{[1
]}

Hoogenraad, NJ ^{[1
]}

Ryan, MT ^{[1
]}

机构：

[1] La Trobe Univ, Dept Biochem, Melbourne, Vic 3086, Australia

来源：

EXPERIMENTAL PHYSIOLOGY | 2003年 / 88卷 / 01期

关键词：

D O I：

10.1113/eph8802501

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The majority of mitochondrial proteins are encoded by nuclear genes, synthesized in the cytosol and subsequently imported into mitochondria through protein translocation machineries of the outer and inner membranes. In this review, we discuss the arrangement of the various translocation complexes and the function of individual import components. We also outline the various targeting pathways that preproteins can take in order to reach their appropriate sub-mitochondrial compartment.

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页码：57 / 64

页数：8

相关论文

共 82 条

[1] Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex [J].

Abdul, KM ;

Terada, K ;

Yano, M ;

Ryan, NT ;

Streimann, I ;

Hoogenraad, NJ ;

Mori, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 276 (03) :1028-1034

[2] Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20 [J].

Abe, Y ;

Shodai, T ;

Muto, T ;

Mihara, K ;

Torii, H ;

Nishikawa, S ;

Endo, T ;

Kohda, D .

CELL, 2000, 100 (05) :551-560

[3] The TOM core complex: The general protein import pore of the outer membrane of mitochondria [J].

Ahting, U ;

Thun, C ;

Hegerl, R ;

Typke, D ;

Nargang, FE ;

Neupert, W ;

Nussberger, S .

JOURNAL OF CELL BIOLOGY, 1999, 147 (05) :959-968

[4] Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria [J].

Ahting, U ;

Thieffry, M ;

Engelhardt, H ;

Hegerl, R ;

Neupert, W ;

Nussberger, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (06) :1151-1160

[5]

ALCONADA A, 1995, MOL CELL BIOL, V15, P6196

[6] Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion [J].

Armstrong, LC ;

Komiya, T ;

Bergman, BE ;

Mihara, K ;

Bornstein, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6510-6518

[7] Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria [J].

Bauer, MF ;

Sirrenberg, C ;

Neupert, W ;

Brunner, M .

CELL, 1996, 87 (01) :33-41

[8] The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom [J].

Bauer, MF ;

Rothbauer, U ;

Mühlenbein, N ;

Smith, RJH ;

Gerbitz, KD ;

Neupert, W ;

Brunner, M ;

Hofmann, S .

FEBS LETTERS, 1999, 464 (1-2) :41-47

[9] FUNCTIONAL AND PHYSICAL INTERACTIONS OF COMPONENTS OF THE YEAST MITOCHONDRIAL INNER-MEMBRANE IMPORT MACHINERY (MIM) [J].

BLOM, J ;

DEKKER, PJT ;

MEIJER, M .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 232 (01) :309-314

[10] Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria [J].

Bolliger, L ;

Junne, T ;

Schatz, G ;

Lithgow, T .

EMBO JOURNAL, 1995, 14 (24) :6318-6326

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