Effect of DL-α-lipoic acid on tissue nucleic acid contents in aged rats

被引：12

作者：

Arivazhagan, P ^{[1
]}

Panneerselvam, C ^{[1
]}

机构：

[1] Univ Madras, Dept Med Biochem, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Chennai 600113, India

来源：

PHARMACOLOGICAL RESEARCH | 2000年 / 42卷 / 03期

关键词：

DL-alpha-lipoic acid; deoxyribonucleic acid; ribonucleic acid and aged rats;

D O I：

10.1006/phrs.2000.0680

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have attempted to evaluate the effect of DL-alpha-lipoic acid on nucleic acid and protein contents in young and aged rats. An age-associated decrease in the deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and protein contents were observed in aged rats. DL-alpha-lipoic acid was administered intraperitoneally (100 mg/kg body weight/day) to young and aged rats from 7 and 14 days. Lipoate administration demonstrated a substantial increase in nucleic acid and protein contents in aged rats. Hence it can be justified that lipoate is functionally efficient in helping the cell to recover from oxidative damage. (C) 2000 Academic Press.

引用

页码：223 / 226

页数：4

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