Chiral palladium(II)-catalyzed asymmetric glyoxylate-ene reaction:: Alternative approach to the enantioselective synthesis of α-hydroxy esters

被引：90

作者：

Hao, J ^{[1
]}

Hatano, M ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol0066983

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An effective chiral palladium catalyst [Pd(CH3CN)(2)(S)-Tol-BINAP](SbF6)(2) (2b) is developed for asymmetric glyoxylate-ene reactions. This palladium dicationic catalyst provides a simple but efficient approach to the asymmetric synthesis of alpha -hydroxy esters in excellent yields with high enantioselectivities at relatively higher reaction temperature (60 degreesC).

引用

页码：4059 / 4062

页数：4

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