Lipid profile, insulin secretion, and insulin sensitivity in psoriasis

被引:74
作者
Reynoso-von Drateln, C [1 ]
Martínez-Abundis, E [1 ]
Balcázar-Muñoz, BR [1 ]
Bustos-Saldaña, R [1 ]
González-Ortiz, M [1 ]
机构
[1] Mexican Inst Social Secur, W Nat Med Ctr, Med Res Unit Clin Epidemiol, Guadalajara, Jalisco, Mexico
关键词
D O I
10.1067/mjd.2003.446
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background. Psoriasis has been associated with an abnormal plasma lipid metabolism and diabetes mellitus possibly related to alterations in insulin secretion and sensitivity. Objective. We sought to identify lipid profile, insulin secretion, and insulin sensitivity in patients with psoriasis and healthy control patients. Methods: A cross-sectional study was performed in 44 nonobese adults, 22 with psoriasis and 22 without. The psoriasis activity was evaluated by the psoriasis area and severity index. Insulin secretion was estimated using the homeostasis model analysis beta-cell function index. Insulin sensitivity was assessed with the insulin tolerance test. Results: High-density lipoprotein cholesterol was significantly decreased in patients with psoriasis (P = .02). There were no significant differences in insulin secretion or sensitivity in patients with psoriasis compared with control patients. Conclusion: Patients with psoriasis had significantly decreased high-density lipoprotein cholesterol concentrations. There were no differences in insulin secretion or sensitivity compared with control patients.
引用
收藏
页码:882 / 885
页数:4
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