RNA-based antiviral immunity

被引：678

作者：

Ding, Shou-Wei ^{[1
,2
]}

机构：

[1] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 09期

基金：

美国国家卫生研究院; 美国农业部;

关键词：

SMALL INTERFERING RNAS; DICER-LIKE PROTEINS; ANIMAL VIRUS-REPLICATION; SMALL SILENCING RNAS; PLANT SMALL RNAS; CAENORHABDITIS-ELEGANS; GENE-EXPRESSION; DROSOPHILA-MELANOGASTER; NICOTIANA-BENTHAMIANA; ARABIDOPSIS-THALIANA;

D O I：

10.1038/nri2824

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity.

引用

收藏

页码：632 / 644

页数：13

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