The Suzuki, the Heck, and the Stille reaction -: three versatile methods for the introduction of new C-C bonds on solid support

被引:91
作者
Franzén, R [1 ]
机构
[1] Univ Helsinki, Dept Pharm, Dept Pharmaceut Chem, FIN-00014 Helsinki, Finland
来源
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2000年 / 78卷 / 07期
关键词
metal-catalyzed coupling reactions; carbon-carbon bonds; solid phase synthesis; combinatorial chemistry; drug discovery;
D O I
10.1139/cjc-78-7-957
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Metal-catalyzed coupling reactions are very efficient and reliable methods for the introduction of new carbon-carbon bonds onto molecules attached to a solid support. This review summarizes recent advances in utilizing the three most used methods, the Suzuki reaction, the Heck reaction, and the Stille reaction, in the field of solid phase organic synthesis resulting in small organic molecule libraries.
引用
收藏
页码:957 / 962
页数:6
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